Four COVID-19 booster doses most effective way to prevent critical Omicron BA.5 Omicron Coronavirus Disease COVID Vaccine Boosters JAMANetworkOpen
Study: Estimated Effectiveness of Prior SARS-CoV-2 BA.1 or BA.2 Infection and Booster Vaccination Against Omicron BA.5 Subvariant Infection. Image Credit: Jo Panuwat D / Shutterstock
SARS-CoV-2 omicron is the most recently emerged VOC with a significantly higher ability to evade pre-existing anti-SARS-CoV-2 immunity than other SARS-CoV-2 VOCs. Among many subvariants of omicron, BA.5 has been found to have the highest ability to evade pre-existing immunity, leading to a significant waning of vaccine efficacy worldwide.
Study design Related StoriesThe study was conducted in South Korea using a case-control study design. Cases referred to individuals who tested positive for SARS-CoV-2 infection during the BA.5-dominated wave. Individuals who tested negative during this period were regarded as controls. The efficacy of a 4-dose vaccination regimen against BA.5 infection was estimated to be 16% in individuals without any previous SARS-CoV-2 exposure. In contrast, vaccine efficacies were estimated to be 89% and 94% in individuals with previous BA.1 and BA.2 infections, respectively.
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