The killings near a nightclub come amid a spike in drug violence in France's second-largest city.
Three men have been shot dead in a car in the southern French city of Marseille, which has seen a recent surge in drug violence.
The latest shooting happened in a residential area of France's second-largest city. The car carrying the five men - all in their 20s - was fired on shortly after they left nightclub around 05:00 .Investigators told French media that the five were known to police and lived in a housing estate where drug crime is rife.
Regional prefect Frederique Camilleri told reporters at the scene that "the entire police force has been mobilised to find the perpetrators of these despicable crimes and to dismantle the networks of the traffickers behind this violence".
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