Man's best friend leads way to early cancer detection LifeAtPurdue
). The study also demonstrated similarities between InvUC in dogs and humans, and defined expected differences in cellular and molecular processes between early cancer detected through screening and later more advanced cancer. The clinical, pathological, and transcriptomic data will be available in the National Cancer Institute’s Integrated Canine Data Commons to allow other scientists to test new hypotheses, thus greatly expanding the value of the study.
The work was also facilitated by the Purdue Genomics Core, and the Collaborative Core for Cancer Bioinformatics supported by the Purdue University Center for Cancer Research NIH grant number P30 CA023168 and the Indiana University Simon Cancer Center NIH grant number P30 CA082709, and the Walther Cancer Foundation, Indianapolis, IN. Elanco, Greenfield, IN, donated deracoxib for the intervention trial. PolyMedco Inc.
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metaMIC: reference-free misassembly identification and correction of de novo metagenomic assemblies - Genome BiologyEvaluating the quality of metagenomic assemblies is important for constructing reliable metagenome-assembled genomes and downstream analyses. Here, we present metaMIC ( https://github.com/ZhaoXM-Lab/metaMIC ), a machine learning-based tool for identifying and correcting misassemblies in metagenomic assemblies. Benchmarking results on both simulated and real datasets demonstrate that metaMIC outperforms existing tools when identifying misassembled contigs. Furthermore, metaMIC is able to localize the misassembly breakpoints, and the correction of misassemblies by splitting at misassembly breakpoints can improve downstream scaffolding and binning results.
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Gut microbiome, cognitive function and brain structure: a multi-omics integration analysis - Translational NeurodegenerationBackground Microbiome-gut-brain axis may be involved in the progression of age-related cognitive impairment and relevant brain structure changes, but evidence from large human cohorts is lacking. This study was aimed to investigate the associations of gut microbiome with cognitive impairment and brain structure based on multi-omics from three independent populations. Methods We included 1430 participants from the Guangzhou Nutrition and Health Study (GNHS) with both gut microbiome and cognitive assessment data available as a discovery cohort, of whom 272 individuals provided fecal samples twice before cognitive assessment. We selected 208 individuals with baseline microbiome data for brain magnetic resonance imaging during the follow-up visit. Fecal 16S rRNA and shotgun metagenomic sequencing, targeted serum metabolomics, and cytokine measurements were performed in the GNHS. The validation analyses were conducted in an Alzheimer’s disease case–control study (replication study 1, n = 90) and another community-based cohort (replication study 2, n = 1300) with cross-sectional dataset. Results We found protective associations of specific gut microbial genera (Odoribacter, Butyricimonas, and Bacteroides) with cognitive impairment in both the discovery cohort and the replication study 1. Result of Bacteroides was further validated in the replication study 2. Odoribacter was positively associated with hippocampal volume (β, 0.16; 95% CI 0.06–0.26, P = 0.002), which might be mediated by acetic acids. Increased intra-individual alterations in gut microbial composition were found in participants with cognitive impairment. We also identified several serum metabolites and inflammation-associated metagenomic species and pathways linked to impaired cognition. Conclusions Our findings reveal that specific gut microbial features are closely associated with cognitive impairment and decreased hippocampal volume, which may play an important role in dementia development.
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Study suggests bats are an underrecognized arenavirus reservoirStudy suggests bats are an underrecognized arenavirus reservoir CDCgov ChariteBerlin FU_Berlin HumboldtUni bats virus virology arenavirus animals wildlife
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The Lily-Rose Depp ‘nepo baby’ interview did not sit well with model Vittoria Ceretti“At the end of the day, you can always go cry on your dad's couch in your villa in Malibu.”
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