Artificialpancreas successfully trialed for use by type 2 diabetes patients Cambridge_Uni NatureMedicine
. We have shown that fully closed-loop insulin delivery does not increase the risk of hypoglycemia despite improved glycemic control and there were no episodes of severe hypoglycemia during closed-loop therapy. The study cohort spent very little time in hypoglycemia during both intervention periods.
Training and maintenance of study devices by participants was acceptable. One participant withdrew because of difficulty managing the devices, whereas all other participants were able to manage the devices independently and reported a high degree of satisfaction while using the closed-loop system. All participants reported that they were happy to have their glucose levels controlled automatically by the system, and 89% reported that they spent less time managing their diabetes overall.
The limitations of the study are that study participants were recruited from a single center and one general practice, and the group was not ethnically diverse, with only one participant not of white ethnicity. Although the present study demonstrated glycemic benefits over the 8-week intervention period, the results should not be generalized beyond this period. The washout period of 2–4 weeks is short for measuring HbA1c.
Ethical and regulatory approvals were obtained from the London-Stanmore Ethics Committee and the Medicines and Healthcare Products Regulatory Agency. The study protocol is provided in the Supplementary Information. The safety aspects of the trial were overseen by an independent data and safety monitoring board. The study is registered with ClinicalTrials.gov .
Australia Latest News, Australia Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Association of shift work with incident dementia: a community-based cohort study - BMC MedicineBackground Some observational studies had found that shift work would increase risks of metabolic disorders, cancers, and cardiovascular diseases, but there was no homogeneous evidence of such an association between shift work and incident dementia. This study aimed to investigate whether shift work would increase the risk of dementia in a general population. Methods One hundred seventy thousand seven hundred twenty-two employed participants without cognitive impairment or dementia at baseline recruited between 2006 and 2010 were selected from the UK Biobank cohort study. Follow-up occurred through June 2021. Shift work status at baseline was self-reported by participants and they were categorized as non-shift workers or shift workers. Among shift workers, participants were further categorized as night shift workers or shift but non-night shift workers. The primary outcome was all-cause dementia in a time-to-event analysis, and the secondary outcomes were subtypes of dementia, including Alzheimer’s disease, vascular dementia, and other types of dementia. Results In total, 716 dementia cases were observed among 170,722 participants over a median follow-up period of 12.4 years. Shift workers had an increased risk of all-cause dementia as compared with non-shift workers after multivariable adjustment (hazard ratio [HR], 1.30, 95% confidence interval [CI], 1.08–1.58); however, among shift workers, night shift work was not associated with the risk of dementia (HR, 1.04, 95% CI, 0.73–1.47). We found no significant interaction between shift work and genetic predisposition to dementia on the primary outcome (P for interaction = 0.77). Conclusions Shift work at baseline was associated with an increased risk of all-cause dementia. Among shift workers, there was no significant association between night shift work and the risk of dementia. The increased incidence of dementia in shift workers did not differ between participants in different genetic risk strata for dementia.
Read more »
Big Pointless Plastic photo contest winners show how our litter plagues natureIt aims to highlight the sad extent to which single-use plastic pollutants have embedded in our natural world
Read more »
Five new nature reserves planned for NottinghamshireThese additional Local Nature Reserves will be created on existing Nottinghamshire County Council green spaces
Read more »
Immunomodulatory fecal metabolites are associated with mortality in COVID-19 patients with respiratory failure - Nature CommunicationsHere, via applying metagenomics and metabolomics analyses, the authors show that fecal microbiota composition and microbiota-derived metabolites predict the trajectory of respiratory function and death in patients with severe SARS-Cov-2 infection, suggesting the gut-lung axis to play an important role in the recovery from COVID-19.
Read more »
Looking Glass Lodge immerses its guests in British natureLooking Glass Lodge by Michael Kendrick Architects is an idyllic woodland retreat in the UK’s East Sussex
Read more »
Early response evaluation by single cell signaling profiling in acute myeloid leukemia - Nature CommunicationsThe molecular mechanisms underlying response to chemotherapy in Acute myeloid leukemia (AML) remain to be explored. Here, the authors perform 36-dimensional mass cytometry in 32 AML patients during intensive chemotherapy and suggest functional signalling analysis for prognosis prediction early after treatment in AML.
Read more »