Could zebrafish's ability to regenerate the heart work in mammals as well?
TREEs into the genomes of embryonic mice and used a visual marker to signify gene activation. They discovered that around half of the enhancers functioned as anticipated and turned tissue blue when and where they sensed tissue damage in the transgenic mammals.
It was demonstrated through a series of studies on mouse heart attack models that viruses containing a TREE could be infused a week before the damage, and the enhancer would then activate when it detected damage. “All three TREEs that we tested could be effective if delivered one day or sometimes longer after the injury -- they could still target expression to the injury,” Poss said. “Is this method of delivering a TREE and a gene going to allow us to deliver a molecular cargo to the right place at the right time? We found that it does in mice.”Pigs, who have far bigger hearts and more human-like heart rates, were also virally given a TREE and a fluorescent marker gene.
They used a mutated YAP controlled by a TREE to test if the muscle grows safely after a heart attack in mice. “The TREE turned on a mutated YAP for a few weeks, just in the injury site, and then it naturally shut down expression,” Poss said.
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