Genetic risk factor found for Covid-19 smell and taste loss, researchers say

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Genetic risk factor found for Covid-19 smell and taste loss, researchers say
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Six months after contracting COVID, as many as 1.6 million people in the U.S. are still unable to smell or have experienced a change in their ability to smell. Scientists think it stems from damage to infected cells in the olfactory epithelium.

the persistent inability or reduced ability to smell and taste impacts relationships, physical health and psychological well-being.

After comparing the genetic differences between those who lost their sense of smell and those who reported that they did not suffer this effect, the study team found a region of the genome associated with this split that’s situated near two genes, UGT2A1 and UGT2A2. Both of these genes are expressed within tissue inside the nose involved in smell and play a role in metabolizing odorants.

To use these findings, scientists need to learn more about how these genes are expressed and what their functions are in olfactory signaling, Turner said.

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