Genetic variant may increase risk for CTE severity among older individuals with repetitive head impacts BUMedicine jamaneuro
. However, the occurrence and severity of CTE varies widely among those with similar RHI exposure.ε4 plays a major role in determining CTE severity and that having"This study provides the most concrete evidence to date thatε4 is a risk factor for CTE-related pathological and clinical outcomes.
Understanding genetic underpinnings of CTE pathology may provide insights into disease mechanism and offers a precision medicine approach to harm reduction, including guiding decisions regarding contact sport play and providing a target for therapies," explains corresponding author Jesse Mez, MD, MS, director of the Boston University Alzheimer's Disease Research Center Clinical Core and a BU CTE Center investigator.
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