Patients with gout may have smaller brain volumes and higher brain iron markers than people without gout, and also be more likely to develop Parkinson's disease, probable essential tremor, and dementia, researchers report.
A novel approach that analyzes brain structure and genetics, Dr. Topiwala and her colleagues combined observational and Mendelian randomization techniques to explore relationships between gout and neurodegenerative diseases. They analyzed data from over 303,000 volunteer participants between 40 and 69 years of age recruited between 2006 and 2010 to contribute their detailed genetic and health information to the Patients with gout tended to be older and male.
Patients with gout and higher urate showed significant differences in regional gray matter volumes, especially in the cerebellum, pons, and midbrain, as well as subcortical differences in the nucleus accumbens, putamen, and caudate. They also showed significant differences in white matter tract microstructure in the fornix.
Gout was linked with higher incidence of Parkinson's disease and probable essential tremor . In asymptomatic participants, urate and Parkinson's disease , but not probable essential tremor, were inversely linked.Using Mendelian randomization estimates, the authors found that genetic links generally reflected their observational findings.
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