Some women struggling to have a baby are turning to Ozempic, but doctors urge caution. What women need to know about weight-loss drug's effect on fertility and pregnancy
Mitchell, who has insulin resistance because of PCOS, says she had no problems getting a prescription. She started taking Ozempic in July of 2022.
The drugs themselves don’t boost fertility, but could put a woman’s body into a more optimal state for conception before she tries to get pregnant, he adds., Robles notes. Obese women can have hormonal disruptions that lead to irregular periods — a signal they’re not ovulating regularly. But even modest weight loss can restore the normal hormonal processes that allow ovulation to happen, he says.
In a statement to TODAY.com, Novo Nordisk, which makes both Ozempic and Wegovy, says it doesn’t have clinical data evaluating the effect of the drugs on fertility treatments.“While we recognize that some healthcare providers may be prescribing Ozempic for patients whose goal is to lose weight, we do not promote, suggest, or encourage off-label use of our medicines,” Novo Nordisk says in the statement.
Dr. Manijeh Kamyar, a maternal-fetal medicine specialist and OB-GYN in Las Vegas, Nevada, says patients usually tell her no one has discussed the risks with them. Animal data from pregnant rodents, rabbits and monkeys exposed to semaglutide showed structural abnormalities in fetuses and early pregnancy losses, according to the prescribing information for Ozempic and Wegovy.
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