Herbert's Los Angeles Chargers will host Wilson and the Denver Broncos in prime time in an AFC West matchup.
Even though there remains nearly three months of the regular season to be played, both quarterbacks have already experienced their share of adversity.
Even though Wilson and the Broncos have struggled under first-year coach Nathaniel Hackett, Chargers boss Brandon Staley remains leery of what Wilson can do. Some of Herbert's best games in his first three seasons have come in prime time. In seven night starts, he has thrown for more than 300 yards four times and has 20 touchdowns against four interceptions.
"I think that the harder part with the prime-time stuff has been our schedule of short weeks then long weeks. As a new staff and team we haven't set the rhythm of a regular week because of all kinds of different stuff."