What are the unknown parts of our genome? Scientists reveal the Unknome database of neglected genes and their potential roles in health and disease.
They warn that ignoring these genes could be a missed opportunity, as they may have important roles in health and disease.
Each knownness score reflects how well a protein is understood by science. A score of zero means nothing is known about it, while a score of 100 means it has been fully characterized. The database allows users to customize their own knownness scores by giving different weights to different factors depending on their research interests. This way, they can prioritize the genes that they want to study.To demonstrate the potential of Unknome, the scientists selected 260 genes that are highly unknown in humans and also present in flies. They deleted each of these genes in fly embryos and observed the effects.
The scientists hope that Unknome will inspire other scientists to explore the unknown parts of our genome and discover new aspects of biology.
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