How does the brain change with age? natureportfolio UCSF Brain Age Changes
By Pooja Toshniwal PahariaJan 19 2023Reviewed by Aimee Molineux In a recent review published in Nature Neuroscience, researchers discussed cellular hallmarks of brain aging and therapeutic interventions to rejuvenate cognitive brain functions.
About the review In the present review, researchers discussed age-associated changes in the brain and therapeutic approaches to reverse them. Concerning inflammatory changes associated with microglia and astrocytes, with an increase in age, a concomitant increase in microglial reactivity, reactive oxygen species generation, complement production, and increased impairments in phagocytosis and synaptic pruning are observed. In addition, astrocytes get reactivated with maladaptive synaptic homeostasis or pruning.
Therapeutic or rejuvenating interventions Neuroscience eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy Therapeutic interventions for cognitive rejuvenation are broadly classified as blood-based and lifestyle interventions. Blood-based interventions to restore cognitive function include heterochronic parabiosis, aged plasma administration, neutral blood exchange, and young bone marrow transplantation.
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