In September, the FDA announced that low levels of a “probable human carcinogen” had been found in some Zantac products. Sanofi—the company that makes Zantac—instituted a voluntary recall of all OTC Zantac products in the U.S. as “a precautionary measure.'
explains. H2 blockers work to reduce heartburn symptoms by binding to proteins in the stomach called histamine H2 receptors.to aid digestion in some key ways, like by increasing the movement of your stomach so it’s better able to churn food. Gastrin also prompts the release of the chemical histamine, which then binds to H2 receptors and causes theto help break down that food. All of that is a normal and necessary part of the digestive process.
But if you have heartburn, your lower esophageal sphincter weakens or relaxes when it shouldn’t. This can cause, meaning that gastric acid can enter your esophagus and lead to heartburn. The goal of taking H2 blockers such as ranitidine is to decrease how much of this acid you make so there’s less of it to flow back into your esophagus and cause those signature symptoms.
The whole issue with NDMA is that studies suggest it’s a “probable human carcinogen,” meaning it has the potential to cause cancer. But the studies in humans linking NDMA to cancer have found a relatively weak link so far.looking at 49 studies on dietary nitrates, nitrites, and NDMA found that a “high” dietary level of NDMA consumption was associated with an increased risk of gastric cancer.
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