Hyperinflammation triggers long COVID headaches Coronavirus Disease COVID PASC LongCOVID biorxivpreprint ClevelandClinic
By Pooja Toshniwal PahariaMar 13 2023Reviewed by Benedette Cuffari, M.Sc. *Important notice: bioRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information.
Background COVID-19 patients may experience persistent symptoms, which is often referred to as post-COVID-19 condition , PASC, or long COVID. Among the long-term neurological symptoms, chronic headache is most commonly reported. Blood samples were obtained between May 2020 to October 2021 from adults with long COVID [LC]-associated chronic headaches and without long COVID [LC] in the post-acute COVID-19 period. The time points for blood collection following headache onset were -8 days, -7 to seven days, eight to 30 days, one to three months, and over three months. Study participants were registered with the Cleveland Clinic COVID registry and Cleveland Clinic BioRepository .
Results Hyperinflammation was involved in triggering the onset of PCC-associated headache symptoms, with sustained inflammation potentially contributing to the development of persistent long COVID headaches. Immuno-metabolic reprogramming among PCC-headache patients may be responsible for the accumulation of lipid and arginine metabolites that contribute to long-term inflammation. The dysregulated metabolism of multiple neurotransmitters could be the hallmark of PCC-associated chronic headaches.
The study findings indicate that chronic generalized inflammation drives COVID headaches, irrespective of COVID-19 severity. Enhanced glucose metabolism and inflammation were also observed among PCC headache patients before headache onset, which likely served as an energy source that subsequently led to a hyper-inflammatory state.
In addition to M1 macrophage-skewing and lipidomic-type profiles among PCC-headache patients, increased arginine and oxo-arginine were observed, with lower expression of nitric oxide synthase inhibitors, asymmetric and symmetric dimethylarginine , and urea. These observations emphasize the essential roles of M1-type macrophage-mediated persistent inflammation among long COVID headache patients.
Australia Latest News, Australia Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
SARS-CoV-2 replication persists for weeks in lungs after symptom onset in severe COVID-19SARS-CoV-2 replication persists for weeks in lungs after symptom onset in severe COVID-19 medrxivpreprint UCT_news LSHTM WitsUniversity lung COVID19 coronavirus covid SARSCoV2 symptom symptoms
Read more »
Researchers identify novel genes that may increase risk for schizophreniaResearchers have identified two previously unknown genes linked to schizophrenia and newly implicated a third gene as carrying risk for both schizophrenia and autism. Led by the Icahn School of Medicine at Mount Sinai, the multi-center study further demonstrated that the schizophrenia risk conferred by these rare damaging variants is conserved across ethnicities. The study may also point to new therapeutics.
Read more »
What are the pitfalls of flow chemistry according to academics and industry professionals?Researchers have shared their 'pain points' of working in flow chemistry.
Read more »
What are the risk factors associated with post-acute SARS-CoV-2 infection?In a recent study posted to the Research Square* preprint server, researchers assessed the risk factors and predictive models for post-acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Read more »
How does SARS-CoV-2 interact with other pathogens?In a recent study published in the PLOS Pathogens journal, researchers examine the present body of information regarding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) interactions.
Read more »
Oscars presenter Glenn Close forced to drop out after positive Covid testAccording to reports actress Glenn Close will be sitting out this year's Academy Awards after testing positive for Covid-19 and is currently ''isolating and resting'
Read more »