‘I can’t really explain it’: Ozempic works, so why is writer Johann Hari conflicted?

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‘I can’t really explain it’: Ozempic works, so why is writer Johann Hari conflicted?
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The bestselling author went down a rabbit hole of research before taking it, emerging slimmer and with a book about the experience.

, which explores the loss of deep focus and attention in modern life. Since early 2023, he’s been taking the weight-loss drug Ozempic: his book about weight-loss medications,, is published next month by Bloomsbury. I interviewed Hari via Zoom. He spoke from a book-lined room in his London flat at 11.30pm his time. He was clearly tired, but funny, charming – and slim.

The worry I have is that is really bad for your health. There are many things I’m unsure of, but one thing I’m confident of is if you are not overweight or obese, I beg you not to take these drugs. You’re incurring all the risks and none of the benefits.Well, we know that if you have successful bariatric surgery, you’re 56 per cent less likely to die of a heart problem; 60 per cent less likely to die of cancer ; 92 per cent less likely to die of diabetes-related causes.

And was only your appetite affected? You talk in the book about dizziness, nausea – and also low mood. This all happens because evolution has not prepared us for super abundance; evolution is about protecting us from famine. The fattest man at the start of the famine will be the last man standing, right? Timothée Chalamet will die in week one, and me at my most KFC-loving will still be alive at the end. No disrespect to Timothée Chalamet – I hope he has a long, happy life. But I think that helps us to understand why diets so frequently and so profoundly fail.

Exactly. You slowly but surely regain the weight. And there’s also debate about whether people develop tolerance – which is basically where your body gets used to a drug, and you have to take higher and higher doses to get the same effect. And no one knows whether that will happen here. Diabetics have been taking these drugs now for 18 years. And they don’t need higher and higher doses.

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