Immune-mediated inflammatory diseases following COVID-19 medrxivpreprint unibirmingham COVID19 SARSCoV2 InflammatoryDisease
By Dr. Priyom Bose, Ph.D.Oct 12 2022Reviewed by Benedette Cuffari, M.Sc. Infection with the severe acute respiratory syndrome coronavirus 2 , the causal agent of the coronavirus disease 2019 , has claimed more than 6.5 million lives worldwide. COVID-19 severity can range from completely asymptomatic to organ failure, sepsis, and death.
Related StoriesIn a recent study posted to the medRxiv* preprint server, researchers explore the potential association between SARS-CoV-2 infection and immune-mediated inflammatory diseases . The mechanisms responsible for IMIDs could include molecular mimicry and system dysregulation during COVID-19. Alternatively, tissue damage and the release of autoantigens could also contribute to the pathogenesis of this condition.
These patients were matched with 1,818,929 adults in the unexposed cohort based on age, sex, and general practice. Individuals in the unexposed cohort neither had a prior diagnosis of IMIDs nor confirmed or suspected SARS-CoV-2 infection. Key findings Compared to the unexposed cohort, the exposed cohort was associated with a 22% relative increase in the incidence of the considered IMIDs during the same period. More specifically, the association between SARS-CoV-2 infection and T1DM, inflammatory bowel disease, and psoriasis was particularly strong.
Strengths and limitations The large sample size of over two million provided sufficient statistical power to infer differences in the incidence of IMIDs across the two groups. Furthermore, important demographic and clinical risk factors were controlled. The study findings could also be generalized, as nationwide data were used.
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