Algorithm offers new way to spot patients likely to respond to immunotherapy icrnews NatureGenet
. We calculated escape dN/dS using the list of 88 genes used in this study. Global dN/dS is the dN/dS values across the whole exome considering all point mutations. Immunopeptidome dN/dS is the value obtained from SOPRANO.Statistical tests were performed using Wilcoxon rank-sum test for two distributions or Kruskal–Wallis test when more than two distributions were present using the R package ggstatsplot, unless explicitly stated in the paper.
) to simulate immune dN/dS under two extreme conditions: fully active immune system and no capacity for immune response . Detailed description of how to run the simulator is on the website. In each condition, we simulated 1,000 tumors starting from an initial pool of five cells, a probability of immune recognition of 10% . Simulations were run until the 100th generation unless they reached carrying capacity before .
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