New data reveals that combining immunotherapy cemiplimab with chemotherapy for advanced non-small cell lung cancer (NSCLC) not only enhances overall survival but also provides quality-of-life advantages. MedEd
The researchers found that the addition of cemiplimab to chemotherapy was associated with a significant, almost 9-month improvement in overall survival. While the trial also highlighted significant improvements in quality of life, functioning, and most symptoms with cemiplimab in comparison with placebo, the current study provides more details on these patient-reported quality-of-life outcomes.
Patients in the cemiplimab arm reported significant improvements in pain symptoms from baseline, as measured with the European Organization for Research and Treatment of Cancer Quality of Life–Core 30 score . Significant delays in the time to deterioration in other functioning and symptom scales favored the cemiplimab group, including dyspnea , nausea/vomiting , and constipation .
No significant improvements in patient-reported outcomes favoring the placebo group were observed on any quality-of-life metric evaluated using the symptom scales.
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