Impact of COVID-19 on diabetic ketoacidosis prevalence among children with type 1 diabetes AUHdk Diabetes Ketoacidosis Prevalence Children COVID19 SARSCoV2
By Pooja Toshniwal PahariaOct 5 2022Reviewed by Aimee Molineux In a recent study, published in The Lancet Diabetes and Endocrinology, researchers evaluated trends in diabetic ketoacidosis prevalence at pediatric type 1 diabetes mellitus diagnosis prior to and post-coronavirus disease 2019 .
SARS-CoV-2-targeted diagnostic efforts delayed several other diagnoses, and the resultant diagnosis at advanced stages was associated with increased mortality rates. An increased DKA prevalence at T1D diagnosis has been observed among children in the initial SARS-CoV-2 wave at several diabetes health centers worldwide.
DKA prevalence rates during 2020 and the consecutive year were compared to estimations based on the pre-SARS-CoV-2 pandemic year trends . Relationships between DKA prevalence changes and COVID-19 severity and measures for containment were investigated based on excessive all-cause deaths in the entire study cohort and the SI values obtained from the OxCGRT database.
Results The final study population comprised 104,290 children, of which 87,228, 8209, and 8853 children were identified with T1D between 2006 and 2019, in 2020, and 2021, respectively. DKA prevalence was greater among females and among children aged <6 years . DKA prevalence at T1D diagnosis differed remarkably among countries, ranging between 20% and 48% .