A team of Northwestern University scientists has developed the first wireless, implantable temperature sensor to detect inflammatory flareups in patients with Crohn's disease.
Mar 18 2024Northwestern University A team of Northwestern University scientists has developed the first wireless, implantable temperature sensor to detect inflammatory flareups in patients with Crohn's disease. The approach offers long-term, real-time monitoring and could enable clinicians to act earlier to prevent or limit the permanent damage caused by inflammatory episodes.
Arun Sharma, whose group led the animal testing, said there is currently no way for clinicians to quickly detect inflammatory events, some of which go unnoticed by patients until the problem becomes so severe that it requires invasive surgery. Sharma said this strategy of measuring temperature fluctuations could also be useful for patients with ulcerative colitis, another inflammatory bowel disease, or any condition where there is a prolonged inflammatory response. In their study, the researchers used the wireless sensors to continuously track temperature fluctuations for nearly four months.
"In addition to the short-term variations, we learned over the span of weeks to months, that the average temperature of the intestines decreases," Madhvapathy said. "This decrease was indicative of the worsening tissue quality over time."
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