A vaccine based on a 100-year-old tuberculosis jab effectively prevents COVID-19 infection in mice – opening a unique path toward a new coronavirus vaccine | liammannix
, a team of Sydney-based scientists showed mice immunised with their vaccine had almost no detectable virus or inflammation in their lungs after exposure to COVID-19.University of Sydney professor Jamie Triccas, head of the team working on the vaccine, said it “compares very favourably with other licensed vaccines’ animal results”. “Clinically, it looks really good,” Professor Triccas said.
Liam Mannix’s Examine newsletter explains and analyses science with a rigorous focus on the evidence.But in recent years, researchers have discovered an ancient property of the immune system: “trained immunity”. Much like hitting the gym builds strong muscles, it seems exposure to certain diseases can change the genes expressed by immune cells, potentially making them more powerful. Think of BCG as the personal trainer.
“We don’t want to overlook protein vaccines. They have a long track record, they tend to be quite effective, they don’t have complicated storage requirements. And you can develop a lot of doses quite quickly,” Professor Triccas said.BCG acts as the vaccine’s adjuvant, telling the immune system to develop antibodies against the spike protein – theoretically providing lasting immunity against COVID-19.
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