Alagille syndrome is a potentially fatal genetic disorder that affects various organs and systems, most notably the liver.
In the latest piece of research, NoRA1 was shown to boost Notch signaling in zebrafish with similar genetic mutations as those found in children diagnosed with the disease.
The survival chances of the zebrafish involved in the study were increased by the application of the treatment. In fact, just a single dose of NoRA1 administered four days after fertilization was enough to achieve a threefold improvement in survival rates. "Our research suggests that nudging the Notch pathway up with a drug could be enough to restore the liver's normal regenerative potential."
There's scope for NoRA1 to help with other common diseases too, so important is the Notch pathway to the proper functioning of everyday biological processes. For now though the focus is on how it can help with this rare liver disease.
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