Organ transplants can quite literally save lives, but they also come with strings attached – often including a lifetime of immunosuppression drug treatments required to keep the immune system in check, lest it reject the transplanted organ as a for
Now scientists are reporting on three successful kidney organ transplants, carried out in children in California, without the need for immune suppression. The transplants used a new method that minimizes the risk of the new kidney getting rejected.
Here, an extra process was added. The researchers performed an alpha-beta T cell and CD19 B-cell depletion, which meant removing the types of immune cells that cause graft-versus-host disease or GVHD – a potentially lethal complication that has been at risk of developing when similar techniques have been used in the past.With a reduced threat of GVHD, the process was much safer.
"This remarkable experience underscores the potential of combined or sequential hematopoietic stem-cell transplantation and kidney transplantation to correct disorders of hematopoiesis and immunodeficiency and to induce tolerance of the kidney allograft," write Thomas Spitzer and David Sachs from Massachusetts General Hospital"SIOD is a rare disorder that involves immunodeficiency, which undoubtedly contributed to the achievement of successful donor HSCT engraftment.
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