Investigating plasma signatures of platelet-derived proteins in acute pulmonary embolism Elsevierconnect uni_mainz_eng MaastrichtU PlasmaSignature PulmonaryEmbolism Platelet
By Neha MathurOct 17 2022Reviewed by Aimee Molineux In a recent study published in Thrombosis Research, researchers determined plasma signatures of proteins related to or derived from platelets in acute isolated pulmonary embolism and deep vein thrombosis-associated PE , compared to isolated DVT .
Human experiments have shown differential platelet activation and reactivity properties in acute VTE. For instance, platelets from acute VTE patients exhibited more exocytosis of dense granules and lysosomes. It accompanied higher plasma levels of thromboxane B2 but less platelet-dependent thrombin generation than patients with excluded VTE, independent of aspirin therapy.
They collected study samples as part of the Genotyping and Molecular Phenotyping of Venous Thromboembolism project undertaken in Germany. The researchers used proximity extension assay technology for high and low abundant plasma proteins profiling from samples stored at -80°C. PEA fetched normalized expression values for all tested plasma proteins integrating oligonucleotide-labeled antibodies and quantitative real-time polymerase chain reaction amplification.
Related StoriesMedication prescription patterns differed accordingly. For instance, antiplatelet therapy, i.e., acetylsalicylic acid and clopidogrel, were overrepresented among PE patients. One explanation is that prophylactic antiplatelet medication is prescribed due to suspicion of myocardial infarction in acute PE patients. It is also possible that varying platelet activity exists between PE and iDVT patients because the proportion of antiplatelet agents is higher in the PE groups.
Relative to iPE, DVT-PE presented one cluster of nine directly interacting plasma proteins related to platelets involved in tissue remodeling and leukocyte trafficking. The tissue inhibitors of matrix metalloproteinases 1 and TIMP4, prominent effectors of tissue remodeling, were more highly expressed in DVT-PE than in iDVT and were secreted from platelet α-granules.
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