A study published in BMCMedicine finds that adult parathyroid cancer patients in Taiwan have a significantly higher incidence of diabetes mellitus, hyperlipidemia, and heart failure than the general population. Further studies are warranted.
Hypercalcemia and insulin resistance are known contributors to metabolic and cardiovascular diseases. Considering the rarity of parathyroid cancer cases and its poor prognosis as a result of its concomitant association with hypercalcemia, there remains a lack of evidence on the long-term metabolic and cardiovascular consequences of parathyroid cancer which requires further attention.
]. The NTCRD has undergone three revisions since inception and has merged with the National Health Insurance Research Database and national death records. We used person-level longitudinal NHIRD registration and claims data between January 1, 2004, and December 31, 2019.Patients were included in the study based on the diagnosis of parathyroid cancer from January 1, 2007, to December 31, 2018.
We performed unadjusted and multivariable Cox proportional hazards regression to estimate hazard ratios and 95% confidence intervals with model 1 adjusted for age and sex reducing the incomplete-matching bias. Further models were adjusted for each outcome, including occupation , urbanization, average monthly income , chronic kidney disease, nephrolithiasis, and osteoporosis. The fulfillment of proportional hazards assumptions for the Cox model was checked using standard methods, log ).
To assess the risk of metabolic and cardiovascular comorbidity progression, the incidence estimated in different years since the parathyroid cancer diagnosis was stratified by outcome.
A sensitivity analysis was performed to assess the metabolic and cardiovascular comorbidities among parathyroid cancer patients compared with the all-covariate-matched general population, including original age, sex, urbanization, occupation, and index year in model and additionally average monthly income , chronic kidney disease , nephrolithiasis , and osteoporosis . All analyses were conducted with SAS, version 9.4 and STATA version 16 , using a 2-tailed test.
Australia Latest News, Australia Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
BMC Series blog Introducing BMC Biomedical Engineering’s Collection: 3D printing in prosthetics
Read more »
NIE confirms it is investigating 'up the Ra' video at bonfireThe video appeared on social media on Wednesday
Read more »
Investigating the role of T-cell immunity in long COVIDInvestigating the role of T-cell immunity in long COVID SciReports Tcell cell longcovid covid coronavirus immunity
Read more »
PSNI investigating footage of 'altercation' in Belfast on TwelfthFootage has appeared online showing an unconscious man lying on the road
Read more »
Taiwan Proposes Tougher Penalties for Sexual Harassers Amid #MeToo WavePresident Tsai Ing-wen’s government moved to strengthen Taiwan’s equality laws after a series of sexual harassment scandals rocked the island’s political elite ahead of a critical election.
Read more »
Man to appear in court charged with ten counts of sexual assaultPolice were investigating a number of alleged sexual assaults between July 7 and July 10
Read more »