Researchers evaluated the impact of sleep-disordered breathing (SDB) on neuroimaging biomarkers of Alzheimer's disease (AD).
By Pooja Toshniwal PahariaAug 21 2023Reviewed by Lily Ramsey, LLM In a recent study posted to the medRxiv* preprint server, researchers evaluated the impact of sleep-disordered breathing on neuroimaging biomarkers of Alzheimer's disease .
Lifestyle factors like exercise and cardiovascular health management can decrease dementia risk. Modifiable risk factors include obesity, hypertension, diabetes, and vascular disease. Stratified subsampling was performed to increase the robustness and reliability of the results and consider imbalanced sample sizes across groups.
Related StoriesAβ PET assessments were performed as a proxy for Aβ plaque burden in the brain; rFDG indicated glucose metabolism as a surrogate of neural activity in the brain; and GMV values indicated brain structure. Linear regression modeling was performed to determine the effect sizes for the interactions between the cognitive scores, GMV, Aβ, rFDG biomarkers, and cerebrospinal fluid biomarkers across the subsamples.
Furthermore, the association effect sizes for cerebrospinal fluid Aβ42 were associated with those for amyloid-beta in the posterior cingulate cortex and right precuneus, GMV in the right and left angular gyri, the fusiform gyrus in the right occipital region, and the regional FDG uptake in the precuneus cortex of the left brain.
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