Kennesaw State professor receives NIH grant to study epigenetic inheritance in nematodes

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Kennesaw State professor receives NIH grant to study epigenetic inheritance in nematodes
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Kennesaw State University biology professor Brandon Carpenter was inspired to pursue a career in science because of an undergraduate research experience. With a recent grant from the National Institutes of Health (NIH), he'll provide a similar experience to his students.

Carpenter, an assistant professor of cellular and molecular biology who studies neurodevelopmental disorders and genetic mutations, received a $432,000 grant to continue research that will help uncover the mechanisms that regulate inheritance of epigenetic states, or "cellular memories," from one generation to the next.

"We can take out a C. elegans gene and put in a human version of that gene and it can rescue that gene, and the worm can function very similarly to the way it did when it had its normal gene," Carpenter said. "We are able to study basic mechanisms in the worm and it's directly relevant to what's happening in humans."

"By studying how these cellular memories turn on the wrong way and affect tissues, we can start to understand the mechanisms of how these patients that have mutations in these same enzymes that regulate the cellular memory have the phenotypes they do," he said.

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