Japanese researchers have discovered that KNT-127, a delta opioid receptor agonist, reduces depression parameters in a mouse model with minimal side effects.
Millions of people throughout the world suffer from depression, which is a serious global health issue. However, current antidepressant medications have many major drawbacks. Addressing this issue, scientists from the Tokyo University of Science and the University of Tsukuba have developed a new, very effective antidepressant medication that has few side effects and operates rapidly to relieve the symptoms of depression.
Furthermore, stress-induced newborn neuronal death in the hippocampus was decreased by KNT-127 treatment but neurogenesis was unaffected. When given the following stress, KNT-127 had no impact on the survival rates of neonatal neurons. KNT-127 also inhibited microglial activation, which decreased inflammation in the hippocampus.
"We expect that the successful clinical development of DOP agonists will greatly broaden the options for the treatment of depression in the future," concluded Prof. Saitoh.Delta opioid receptors play an important role in depression and other mood disorders. However, little is known about the underlying physiological mechanisms. The hypothalamic–pituitary–adrenal axis, adult hippocampal neurogenesis, and neuroinflammation are regarded as key pathophysiological factors in depression.
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