Large COVID vaccination study found that thrombosis and thrombocytopenia are very rare complications Coronavirus Disease COVID Cardiology Thrombosis Thrombocytopenia NatureComms UniofOxford UV_EG UniBarcelona
By Neha MathurNov 28 2022Reviewed by Benedette Cuffari, M.Sc. In a recent Nature Communications journal paper, researchers determine the rates of thrombosis, thrombocytopenia, and thrombosis with thrombocytopenia following severe acute respiratory syndrome coronavirus 2 vaccination and infection. These rates were compared with background rates assessed in the general population of the United Kingdom.
About the study In the present study, researchers assessed six cohorts of individuals from the U.K. general population to study the effect of COVID-19 vaccination. Four vaccinated cohorts included individuals vaccinated with ChAdOx1 or BNT162b2 vaccines. These individuals received either their first or second dose between December 8, 2020, and May 2, 2021, and were followed up with until 28 days from the index date.
Diagnostic codes were used to identify five venous thromboembolic events including cerebral venous sinus thrombosis , pulmonary embolism , splanchnic vein thrombosis , deep vein thrombosis , and the composite event venous thromboembolism , which encompassed DVT and PE. Two arterial thromboembolic events including myocardial infarction and ischemic stroke were also identified.
Among first-dose recipients of both vaccines, IRRs increased among younger age groups, with IRRs reaching one for all age groups in the SARS-CoV-2 RT-PCR-positive cohort. This cohort had observed vs. expected VTE of 1090 and 150, with a SIR of 7.27.
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