The treatment made a huge difference in the quality of life for trial participants.
of the skin together. The absence of the protein causes the layers to slide across each other, resulting in blisters that form painful open wounds.
The herpes virus has evolved to evade the human immune system, the release said, so the gel can be applied repeatedly without triggering an immune response."We saw no inflammation, significant side effects, or immune neutralization of the drug, even with repeated administration of the gel over the six months of the trial period," Marinkovich said.
The researchers will also try the gel on patients' hands and mucosal surfaces, including the mouth, throat, eyes, esophagus, and anus. Methods: We conducted a phase 3, double-blind, intrapatient randomized, placebo-controlled trial involving patients 6 months of age or older with genetically confirmed dystrophic epidermolysis bullosa. For each patient, a primary wound pair was selected, with the wounds matched according to size, region, and appearance. The wounds within each pair were randomly assigned in a 1:1 ratio to receive weekly application of either B-VEC or placebo for 26 weeks.
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