Lipid-peptide nanocomplexes offer new mRNA platform ucl mRNA LipidPeptide Nanocomplexes
By Dr. Liji Thomas, MDJun 27 2022Reviewed by Aimee Molineux Scientists are constantly seeking to improve the efficiency of the delivery of biologically active particles to the body tissue, using novel vehicles and adjuvants.
Since the mRNA is not incorporated into the chromosomal DNA, the genotoxic effects are much less likely. Moreover, its manufacture is much easier than that of DNA plasmids. The latter are also much larger, about 5-10 kb, with a double-stranded supercoiled structure, compared to the linear single-stranded nature of mRNA.
Findings The authors followed a systematic approach to optimize a nanocomplex of lipids and peptides in electrostatic complex with mRNA, and identified some of the unique features that may be helpful in taking these findings further for mRNA-based therapeutic agents. DOPE and peptide 35 were included in most of the top formulations, and those with RVRR linkers. This suggests that the helper lipid must be chosen carefully, both for its own properties and in combination with the other components of the formulation.
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