'Lost' immunecells partly to blame for reduced vaccine response in olderpeople BabrahamInst natimmunol
have lower levels of protection from vaccination which also wanes more quickly compared to younger people. Protection by vaccination is essential to protect older people who become more susceptible to infections with age.can be reversed or mitigated is an important part of securing better health in later years.
Through a combination of mouse research, computer modeling and analysis of human vaccination data, the Linterman lab research team were able to show that changes to key interactors of B cells in the light zone of the germinal center, T follicular helper cells, and also to light-zone specific cells called follicular dendritic cells , were at the heart of the diminished vaccination response.
"What we found is that the T follicular helper cells aren't where they should be and as a result, antibody-producing cells lose essential selection cues. Surprisingly we also uncovered an unknown role for T follicular helper cells in supporting the expansion of follicular dendritic cells in the light zone after vaccination."
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