Newly identified protein drives breast cancer stemness and metastasis northwesternu elife
Malignant peripheral nerve sheath tumors are aggressive sarcomas that typically carry a dismal prognosis. Given the insensitivity of these tumors to traditional chemotherapy and the absence of effective targeted drugs, new therapeutic strategies are urgently needed. Photothermal therapy including near-infrared laser at the third biowindow has demonstrated significant potential in cancer theranostics due to its minimally invasive nature and excellent therapeutic outcomes.
The tumor xenografted mice model was used for evaluating the efficacy and biosafety of NIR-III photothermal ablation. Finally, the underlying mechanisms of NIR-III treatment, explored by whole-transcriptome sequencing, are further verified by RT-qPCR.