A contraceptive drug that stops sperm from moving for 2 hours was 100 per cent effective at preventing pregnancy in mice
A drug that temporarily paralyses sperm could become the first on-demand male birth control pill. In mice, the contraceptive was 100 per cent effective at preventing pregnancy for about 2 hours, with full fertility returning 24 hours later.at Cornell University in New York. Most other prospective male contraceptives in clinical development are only effective after eight to 12 weeks, he says.
Previous research has shown that sperm require a protein called soluble adenylyl cyclase to move, and that men who cannot produce sAC due to rare genetic mutations are infertile. So, Buck and his colleagues assessed whether a drug inhibiting sAC could be used as a male contraceptive. If sperm are immobile, they can’t travel up the vaginal tract to fertilise an egg.The team assessed the movement of sperm collected from 17 male mice, eight of whom received the drug.
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