Errors in the human genome are a part of life. As we age and DNA replicates, small mistakes creep into our genes – a misplaced letter here or some erroneous repetition there – that can accumulate over time to create a 'mosaic' of cells with uniqu
One example of this is a condition whereby white blood cells are missing their Y chromosome. Called mLOY , it's more common than you might think, occurring in roughly 40 percent of men aged over 70.genetic wasteland full of dispensable chunks of DNA, missing a Y chromosome can have serious health consequences.of age-related diseases, such as cancer and Alzheimer's disease.
For a while it has been unclear how losing the Y chromosome from blood cells leads to organ damage and disease in other parts of the body, and ups the risk of age-related maladies, particularly cardiovascular disease and stroke.aka Metropolitan University Graduate School of Medicine in Japan, probed those questions a little deeper, and have shown how mLOY triggers tissue damage that leads to heart failure in mice and is linked to cardiovascular disease.
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