Tensions between the brain, the gut, and the makeup of its microbial inhabitants appear to play a critical role in the development of neurodegenerative conditions.
Using the largest ever genome-wide association study of human gut microflora, a team of researchers from the US sought out a more explicit relationship between Alzheimer's disease and the mix of organisms living inside the digestive system.
Their analysis, published in March 2023, uncovered not only a genetic connection between different genera of gut bacteria and a diagnosis of Alzheimer's but also a link between the microbes and a genetic risk factor for the neurodegenerative disorder. The study further emphasizes the interplay of genetic factors and inflammatory gut microflora in healthy brain function.that strike a tentative truce with the immune system. For the most part, this arrangement is mutually beneficial. The microbes get a place to live, and we get a front-line defense of tiny occupants willing to protect their home.
That's not to say the balance is always a harmonious one. Shifts in our immune system can give some species an advantage over others. Likewise, changes in the makeup of microbes – by way of, for example – can profoundly affect the body's functioning. For better and worse. The tug-of-war between our microbial census and general health can ripple throughout the body in less than predictable ways, sowing confusion in how
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