Michael J. Mitchell is developing lipid nanoparticles to deliver therapy to specific organs such as the lungs and brain.
Messenger RNA became a household term when it was used as the backbone of the first COVID-19 vaccines,to two mRNA pioneers at the University of Pennsylvania.
The idea of using lipids to encapsulate various types of drugs for delivery has been around for several decades. In the context of mRNA delivery, in the early 2000s, the major discovery was creating what is known as the ionizable lipid nanoparticle . Because of the ionizable nature of the lipids, when they come into contact with acidic buffer, those lipids become charged. That charge mechanism then binds the RNA to the lipids.Were you at Penn when Drew Weissman and Katalin Karikó published their first findings on mRNA in 2005?Before I got to Penn, in 2018, I was in Bob Langer’s lab at MIT as a research fellow. He’s one of the founders of Moderna. He’s considered kind of a father of the drug-delivery field.
How do we get RNA to other parts of the body? How do we get into the brain? How do we get into the lungs for cystic fibrosis and lung cancer?Tell me about that study where you got mRNA into the lungs of mice. We tagged the different kinds of lipid nanoparticles with a bar code of DNA, so we could identify them using next-gen sequencing technology. We can essentially count the number of LNP delivered to specific parts of the body by using those bar codes.
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