Meta-analysis confirms 17 key metabolites as strong predictors of gout Nutrients_MDPI gout metabolites metaanalysis preditors prevention research
By Neha MathurJul 18 2023Reviewed by Lily Ramsey, LLM In the present study published in Nutrients, researchers summarized published scientific literature describing the use of metabolomics to detect metabolites in gout patients, with particular attention to biomarkers that provide an early prediction of gout.
Doctors treat acute gout with high doses of drugs, such as glucocorticoids and colchicine. However, there is increasing evidence that medication adherence to these therapies is poor worldwide. Thus, prevention of acute and chronic gout and its early diagnosis appears to be the most cost-effective path for reducing healthcare costs.
They used the standardized mean difference of 46 metabolites and 95% confidence intervals of 95% for the meta-analysis across studies, where they considered heterogeneity as substantial only when above 60%. The current analysis found a characteristic metabolite profile for gout, in which 10 of 46 metabolites showed marked differences, and nearly all were related to metabolic inflammation.
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