Meta-analysis showcases the long-term benefits of COVID-19 vaccines against hospitalization & death Coronavirus Disease COVID Vaccines LancetRespirMed mbmc_cmcm CADTH_ACMTS Concordia
By Neha MathurFeb 14 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in The Lancet Respiratory Medicine, researchers performed a systematic evidence synthesis and meta-analysis on the long-term vaccine effectiveness of four coronavirus disease 2019 vaccines, including ChAdOx1 nCoV-19, messenger ribonucleic acid -1273, BNT162b2, and Ad26.COV2.S.
Manual searches of published literature in French or English documenting VE immediately, within 112 days post-completion of a primary vaccination series, or 84 days post-boosting were also performed. While some reviewers assessed study titles, abstracts, and full text to extract data, another researcher verified the identified studies.
The VE of the primary COVID-19 vaccination series was initially recorded to be about 83% between 14 and 42 days after the two-dose vaccination regime was completed. However, VE markedly decreased within 112 days post-vaccination and ultimately diminished to 47% by 280 days. The study data suggest that vaccination conferred consistently durable protection against hospitalizations and mortality. However, this protection was modest against breakthrough infections.
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