People with diabetes who started taking metformin had a significantly lower incidence of dementia. MedTwitter
Type 2 diabetes is a well-established risk factor for dementia and PD, suggesting that metformin might reduce the risk of these neurodegenerative diseases, but findings from prior studies have been inconsistent, and these studies also had important limitations.
The findings highlight the need for careful consideration of age, race, and renal function when selecting participants in clinical trials that address the benefits and safety concerns associated with repurposing of metformin.of patients in the United States. They focused on patients with diabetes who were at least 50 years old.
The researchers applied propensity score adjustment that incorporated 33 demographic and clinical variables.The study population included 96,140 new users of metformin and 16,451 new users of sulfonylurea.level was about 6.8%; 48% were men; and about 83% were White. New users of metformin also had a significantly lower risk of AD . The rate of vascular dementia was reduced by a similar amount ; this was on the cusp of significance. The adjusted incidence of MCI showed a point estimate reduction, which was not significant.
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