An article in BMCPalliatCare discusses PALSED: a study of similarities and differences in indication, practice and specific outcomes of palliative sedation in patients with advanced cancer with refractory symptoms across five European countries.
). When informed consent is gained, baseline information for all patients is collected for phase 1. Then study measurements are paused and participants are clinically followed by the health care team.Study flow phase 1 and phase 2.
]. The ECOG performance score is completed by one of the attending physicians or clinical researchers as a baseline measurement in this study.The Discomfort Scale-Dementia of Alzheimer Type is a validated instrument to assess discomfort in patients with severe dementia by observing patients’ behavior over 5 minutes of observation. Participating health care teams were trained online and at bedside how to use the DS-DAT tool.
This medication list contains information about: 1) Changes in dosages of sedative medication which is recorded in numbers and units ; 2) Changes in the sort of sedative medication used for palliative sedation which are recorded with the medication name; 3) Changes in the route of administration of sedative medication. All changes will be recorded with the accompanying date and time.
Differences between settings will be tested through a Chi-square test for categorical variables , Kruskal-Wallis test for ordinal variables, and ANOVA for continuous variables.
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Eczema as a protective factor for brain cancer: a meta-analysis - BMC CancerBackground Brain cancer is one of the most aggressive cancer types owing to poor treatment effects. Epidemiological studies have demonstrated that allergies may increase the disease risk. Therefore, this study evaluated the association between eczema and the risk of various brain cancers. Methods We systematically searched the PubMed and Embase databases from their inception until June 23, 2022. Two reviewers independently reviewed and screened the articles, extracted data, assessed the study quality, and pooled the results. Stata software was used to generate pooled odds ratios and 95% confidence intervals (CIs). Results We included 20 studies comprising 5,117,222 patients that investigated the relationship between eczema and brain cancer. Eczema was significantly inversely associated with the risk of brain cancer (odds ratio [OR], 0.82; 95% CI, 0.77–0.87), glioma (OR, 0.53; 95% CI, 0.14–2.02), meningioma (OR, 0.74; 95% CI, 0.66–0.84), and acoustic neuroma (OR, 0.60; 95% CI, 0.41–0.88). Interesting, The strong correlation between eczema and the reduced risk of brain cancer was observed in people over 16 years old (OR, 0.79; 95% CI, 0.71–0.88), but not in those under 16 years old (OR, 0.94; 95% CI, 0.79–1.11). In addition, subgroup analyses found that eczema significantly decreased the glioma risk in Europeans (OR, 0.73; 95% CI, 0.65–0.82) but not Australians (OR, 0.53; 95% CI, 0.14–2.02) or Americans (OR, 1.01; 95% CI, 0.69–1.46). Conclusion Eczema may be considered as a potential protective factor of brain cancer in population aged over 16 years. However, this relationship requires verification using large-scale clinical data.
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