Scientists Develop New Method to Faster – and More Accurately – Find Antigens That Trigger Specific Immune Cells A cell’s secrets can be revealed by its surface. It is decorated with tens to hundreds of thousands of molecules that help immune cells determine friend from foe. Some of those protrudin
Scientists have developed a new method to faster and more accurately predict which antigens will lead to a strong immune response. This could help researchers develop more effective cancer immunotherapies.
A team of Stanford scientists has developed a new method to faster and more accurately predict which antigens will lead to a strong immune response. Their approach could help researchers develop more effective cancer immunotherapies. The study was led by Polly Fordyce, an Institute Scholar at Sarafan ChEM-H, and will be reported today in the journalT cells, a class of immune cells, crawl along and squish past other cells as they patrol the body.
“It’s kind of like a Chinese finger trap,” said Fordyce. “When you pull a bit at the receptor-antigen interaction, the binding actually lasts longer.”Identifying the best antigen-receptor pairs requires simultaneously applying that sliding, or shear, force between a peptide and a T cell and measuring T cell activation. Ideally, this would be done thousands of times to get repeatable data for many possible peptide/T cell receptor pairs.
They could do hundreds of individual experiments in parallel by using beads that are each labeled with a unique color, making it possible to track multiple different pMHCs. They took two sets of pictures tiling across each slide after each run: one set that tells them which pMHC a given bead is displaying and another that tells them how active each T cell atop that bead is. Cross-referencing those images tells them which antigens led to the strongest T cell responses.
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