Although not quite meeting its primary endpoint, a new trial has added to evidence suggesting that patients with large ischemic strokes who have a significant amount of brain tissue damage may still benefit from thrombectomy.
) have shown that patients with large core infarcts can still benefit from endovascular thrombectomy.
The TESLA trial results were presented at the recent European Stroke Organisation Conference, held in Munich, Germany. The number of patients achieving functional independence was 14% in the thrombectomy groups vs 9% in the control group ; and a good functional outcome was achieved in 30% of thrombectomy patients vs 20% of those in the control group . Quality of life, measured by the EuroQol 5 Dimension 5 Level survey, also showed a trend towards improvement in the thrombectomy group with mean scores of 53 vs 46 .
The RESCUE Japan Limit trial was conducted in Japan; the SELECT-2 trial in North America, Europe, Australia, and New Zealand; and the ANGEL ASPECT trial in China. “The results from the previously published large core trials and from this pooled dataset provide unequivocal evidence on the efficacy and safety of endovascular thrombectomy in patients with large core infarcts," lead author of the MAGNA meta-analysis, Amrou Sarraj, MD, professor of neurology at University Hospitals Cleveland Medical Center, affiliate of Case Western Reserve University in Cleveland, Ohio, concluded.
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