mRNA boosters associated with decreased odds of hospitalization compared with the mRNA vaccine primary series alone JAMA_current UChicago providence mRNA booster vaccine vaccination COVID19 coronavirus covid
By Bhavana KunkalikarSep 28 2022Reviewed by Danielle Ellis, B.Sc. In a recent study published in JAMA Network, researchers assessed the chances of coronavirus disease 2019 hospitalization after three versus two messenger ribonucleic acid vaccine doses.
About the study The team examined the relationship between the initial mRNA vaccination series alone versus the COVID-19 mRNA booster immunization and the likelihood of COVID-19 hospitalization. Each patient case was matched with four controls who had their second dose of COVID-19 vaccination within seven days of diagnosis and were hospitalized non-electively for causes other than a SARS-CoV-2 infection within three days. From electronic medical records, the team gathered information on demographics, COVID-19 vaccination data, comorbidities, and history of COVID-19 positivity.
Results The study included a total of 12,248 matched controls with an average age of 67.1 years, 46.7% of whom were men, while 3062 COVID-19 cases had a mean age of 70.8 years, of which 52.6% were men and 34.7% were boosted. Factors that showed higher chances of hospitalization due to COVID-19 were the age of 70 years or more, male gender, cognitive illness, diabetes, chronic obstructive pulmonary disease, obesity, immunodeficiency, transplant, rheumatologic disease, and BNT162b2 vaccination.
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