Nanocomposite Mimics Skin to Treat Wounds in One Dose: ACS_AMI nanomedicine WoundHealing Nanotechnology nanocomposite
By Bhavna KavetiJul 19 2022Reviewed by Susha Cheriyedath, M.Sc. Hydrogels are promising candidates that mimic the native skin microenvironment due to their porous and hydrated molecular structure.
The NF-reinforced HG matrix was composed of sodium alginate and gelatin , antimicrobial Punica granatum extract along with hyaluronic acid . Furthermore, the HG nanocomposites crosslinked with N-propyl)-N′-ethyl carbodiimide hydrochloride were reinforced with fragmented trans-ferulic acid -loaded cellulose acetate/polycaprolactone NFs.
Nanocomposites in Wound Healing Process Wound healing is a complex skin repairing process that begins immediately after an injury to the epidermal layer and might take days to years. This dynamic wound healing process includes highly organized cellular, humoral, and molecular mechanisms. Wound healing has three overlapping phases: inflammation, proliferation, and remodeling. Any disruption to these phases could lead to abnormal wound healing.
Although the porosity of hydrogels enables the absorption of exudates and maintains the moisture balance, they lack mechanical properties and are highly susceptible to degradation. However, the insertion of nanofibers into the hydrogel crosslinked matrix results in hybrid fortified nanocomposites, which exhibit optimal pore structure that maintains the water balance and prevents cell migration in 3D hydrogels.
Additionally, the designed skin substitute endowed tunable mechanical properties, excellent physical properties, and a highly porous microstructure. The characterization results revealed that the plain and FA-loaded NFs had average diameters of 210 ± 12 and 452 ± 25 nanometers, respectively. Conclusion To summarize, a skin substitute mimicking the natural ECM was fabricated by reinforcing the HG matrix with NFs. The developed HG nanocomposites were incorporated with key components of native ECM. Consequently, the skin substitute was composed of GE/SA HG fortified with fragmented PCL/CA NFs.
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