Nanoparticles take aim at COVID-19 with lysosome-targeted delivery COVID19 Nanoparticles ViralInfection Lysosome DrugDelivery SARS_CoV_2 InhalableNanoparticles Mefloquine Omicron HealthScience biorxivpreprint UCLA BU_Tweets dgsomucla
By Bhavana KunkalikarMay 15 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study posted to the bioRxiv* preprint server, researchers discuss the use of endo-lysosome-targeted nanoparticles for delivering antiviral therapy to treat coronavirus infections.
Clinical trials of CQ/HCQ and LPV/RTV for COVID-19 patients did not show significant clinical benefits as compared to standard care, despite promising in vitro reports. Therefore, a potent antiviral therapy for coronaviruses that impacts the pulmonary system locally is crucial to address this unmet need.
Related StoriesThe team assessed NP cytotoxicity in vitro in human lung fibroblast , Calu-3, and Vero E6, cell lines over 24 hours using a tetrazolium-based MTS assay. Two cell lines were used to evaluate the effectiveness of MFQ-NP against the severe acute respiratory syndrome coronavirus 2 . At 72 hours, Calu-3 and Vero E6 cells had MFQ-NP IC50 values of almost 206 μg/mL and 269 μg/mL, respectively. This corresponded to approximately 35.8 µM and 46.8 µM of loaded MFQ.
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