Nature research paper: Neuropathic pain caused by miswiring and abnormal end organ targeting
, in which Cre recombinase is transgenically driven by 110-kb promoter elements of the mouse Nav1.8-encodinggene to obtain SNS-mGFP or SNS-tdTomato mice that express fluorescent marker in peripheral nociceptive sensory neurons. Mice expressing YFP under the control of the Thy1 promoter were obtained from The Jackson Laboratory; stock no. 003709. In these mice, non-nociceptive sensory neurons are labelled.
guidelines were followed. Sample sizes were based on previous experience with G-power analyses. Only adult mice were used. Mice of both sexes were tested in imaging, behavioural and electrophysiological experiments and in all experiments, mice were randomized and experimenters were blinded to the identity of the treatment groups.
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