Non-alcoholic fatty liver is associated with increased risk of irritable bowel syndrome: a prospective cohort study - BMC Medicine

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Non-alcoholic fatty liver is associated with increased risk of irritable bowel syndrome: a prospective cohort study - BMC Medicine
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High degree of non-alcoholic fatty liver as well as non-alcoholic fatty liver disease is associated with increased risk of incident irritable bowel syndrome, according to a study published in BMCMedicine.

]. Potential confounders included age , gender , ethnicity , socioeconomic status, education level, smoking status , alcohol drinking , type 2 diabetes and physical activity. Socioeconomic status was based on the Townsend deprivation index, which was calculated immediately prior to participants joining UKB using preceding national census output areas []. Townsend deprivation index for socioeconomic deprivation was divided into four quartiles.

For FLI quartiles, per standard deviation change of FLI and diagnosis of NAFLD or not according to predefined cutoff, three multivariable models in addition to univariable analysis were accomplished: model 1, adjusted for age and gender; model 2, additionally adjusted for Townsend deprivation index, education level, ethnicity, smoking status, and alcohol drinking; model 3, additionally adjusted for physical activity and type 2 diabetes.

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