Researchers explore the potential utility of ginger essential oil in preventing NASH.
By Dr. Liji Thomas, MDAug 29 2023Reviewed by Benedette Cuffari, M.Sc. Non-alcoholic steatohepatitis , which is a type of non-alcoholic fatty liver disease , arises due to hepatic fat accumulation, which subsequently leads to inflammatory damage to the liver. Untreated NASH may progress to liver cirrhosis and liver cancer.
Introduction NAFLD is the most common chronic liver condition worldwide. NASH is characterized by at least 5% fat deposition in the liver and is often accompanied by inflammatory and hepatocyte changes, as well as hepatic fibrosis in some cases. Furthermore, HFD increases permeability of the intestinal epithelial barrier, thereby allowing pathogens to enter portal and systemic circulation. These present pathogen-associated molecular patterns to the liver, including lipopolysaccharides from gram-negative bacteria.
The PL group also exhibited higher alanine aminotransferase levels, which is a marker of liver damage, whereas AST levels were comparable to those in the control group. GEO supplementation at moderate to high doses reduced ALT levels as compared to the PL group.
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