Novartis is halting a UK-based trial originally planned as part of a partnership with NHS England, a setback in its quest to win wider approval for its novel cholesterol-lowering drug to prevent heart attacks and strokes.
The company's logo is seen at the new cell and gene therapy factory of Swiss drugmaker Novartis in Stein, Switzerland, November 28, 2019. REUTERS/Arnd WiegmannNovartis to pursue different Leqvio trial insteadis halting a UK-based trial originally planned as part of a partnership with NHS England, a setback in its quest to win wider approval for its novel cholesterol-lowering drug to prevent heart attacks and strokes.
Under the ORION-17 trial, planned to involve 40,000 patients, Novartis was trying to show that its Leqvio drug could prevent the first occurrence of major cardiovascular health problems in high-cholesterol patients, part of a broader collaboration with the British health system. The drug is approved to prevent renewed cardiovascular crises like a heart attack or stroke in people who have already suffered one, known as secondary prevention.
Leqvio, a twice-a-year injection, has had a slow ramp-up phase because cardiologists need to be persuaded to change their billing routines, but analysts have predicted a more than $2 billion sales opportunity from 2025. It would be among the company's biggest growth drivers during that time.
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